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Clinical Evaluation of Antitumor Therapy

Services of the Antitumor Assessment Core Facility are available on a first-come, first-served basis to all investigators at Memorial Sloan Kettering. All requests for services must first be approved by the facility head, who also helps investigators in planning the studies to be conducted and provides them with an estimate of the final cost. Specialized requirements of individual investigators are considered on a case-by-case basis following evaluation of feasibility by the facility management.

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[Clinical evaluation of the antitumor effectiveness of spirobromine].

Technical and Advisory Services Provided Cell lines and tumor tissues : We maintain a large repository of commonly used murine and human cell lines and tumor tissues. Xenografts : We establish xenograft models from cell lines or tumor samples provided by the investigator or supplied through our repository. Successfully engrafted tumors are propagated by serial transplantation and cryopreserved for future use.

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Efficacy studies : We evaluate in vivo efficacy of agents either alone or in combination with standard chemotherapy regimens against murine tumors, human tumor xenografts, and transgenic mouse models of human cancer. Previously, successful studies of adoptive immune therapy have included the use of IL-2 after cell therapy administration. Administration of these cells is safe.

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Nat Rev Immunol 6 : — Download references. Correspondence to A J Nicol.

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This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3. The Journal of Immunology Immunological Investigations Molecular Therapy